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Hyperglycaemia activates the NF-B and JNK pathways, leading to pro-inflammatory milleu, impaired insulin signalling and insulin resistance in several insulin-responsive tissues, such as hepatocytes, skeletal muscles, adipocytes and endothelial cells [17, 18]

Participants were randomized to one of four arms: half a fresh grapefruit before each meal, 8 oz of grapefruit juice three times a day, a placebo capsule, or a grapefruit extract capsule

Blood sugar levels, measured by HbA1c, fell by an average of 2.0% from a baseline of 7.9%

DPP-4 inhibitors are increasingly replacing sulfonylureas as insulinotropic agents, but they can frequently also be a good therapeutic alternative to other treatment options such as glitazones or glucosidase inhibitors

Clinical trials show no serious side effects