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Until nowdespite extensive studies of the tyrosinase reaction based on the crystallographic analysis, low-molecular-weight model systems, and computer simulationsthe catalytic mechanism was unclear at an atomic level
It recruits Parkin for downstream ubiquitin clearance of the damaged mitochondria, also known as mitophagy
Furthermore, the well documented efficacy of combined folic acid, B6, and B12-vitamin supplementation to reduce hyperhomocysteinemia could enhance GSH activity and reduce oxidative stress (161)
doi: 257 DaniMDirksenATaraborrelliPTorocastroMPanagopoulosDSuttonRet al
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