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We illustrate significance in the figures of this manuscript with the following conventions: p 0.05 is denoted with *, p 0.01 is denoted with ** and p 0.001 is denoted with ***

Solubility Enhancement: Studied for its role as a universal polar solvent, facilitating the dissolution of lyophilized powders for precise dosing

Sucrose solution (prepared in tap water) was placed in one bottle and tap water in the other

Ecotoxicology 5:217225 Van Ravenzwaay B, Coelho-Palermo Cunha G, Leibold E, Looser R, Mellert W, Prokoudine A, Walk T, Wiermer J (2007) The use of metabolomics for the discovery of new biomarkers of effect