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doi: 10.1016/j.jep.2024.117887 93 LiuYSongCGaoSZhouDLvJZhouYet al

and in terms of vascular barrier function, the loss of HS exposes adhesion molecules, promoting the adhesion of leukocytes and platelets, triggering inflammation and thrombosis, and further impairing renal blood supply and glomerular filtration, ultimately leading to a decrease in GFR (100)