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Two main pathways can trigger this process, the intrinsic, also called mitochondrial pathway, when apoptosis is initiated by the internal signals of mitochondrial origin, and the extrinsic when apoptosis is activated by external stimuli [16]

The ACG (2018) recommends the following surveillance protocol: For BE patients without dysplasia, endoscopic surveillance should take place at intervals of 3 to 5 years Patients diagnosed with BE on initial examination do not require a repeat endoscopy in 1 year for dysplasia surveillance For patients with indefinite for dysplasia, a repeat endoscopy after optimization of acid suppressive medications for 36 months should be performed