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Table 4 shows adverse reactions reported in greater than or equal to 3% of WEGOVY-treated pediatric patients and more frequently than in the placebo group from a study in pediatric patients aged 12 years and older

The New England Journal of Medicine commentary accompanying SURPASS-2 stated: "The dual incretin approach appears to exploit receptor crosstalk in ways that amplify downstream insulin secretion beyond what GLP-1 receptor agonism alone can achieve at comparable tolerability." [30] SURPASS-1: Monotherapy Benchmark SURPASS-1 (N=478) established monotherapy efficacy, with tirzepatide 15 mg reducing A1C by 2.07 percentage points and body weight by 9.5 kg at 40 weeks versus placebo [31]

They require careful medical assessment, especially in individuals with: Certain gastrointestinal disorders A history of pancreatitis Specific endocrine conditions Pregnancy or those planning pregnancy A personalized consultation is essential before starting therapy

J Clin Invest 1985

doi: 10.1161/STROKEAHA.113.002637 83 ButovskyOZivYSchwartzALandaGTalpalarAEPluchinoSet al