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Effects on curvature and plaque were not evaluated in the randomized phase but curvature improvements were noted in 23% of patients and plaque reductions in 47% of patients in the open-label phase

Moreover, the levels of vascular VEGF, angiopoietin, and platelet-derived growth factor (PDGF)-B&D were restored

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Since the subjects were block-randomized and technicians were blinded to the treatment, it is highly unlikely that mitochondrial sample preparations, contamination of samples, substrates fed to the mitochondria or the performance of high-resolution respirometers influenced these results