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In serum, first-episode, antipsychotic-nave patients show reductions in TRP, KYN, KYNA, anthranilic acid, and modestly lower 3-HK and QA, indicating early KP dysregulation, and long-term antipsychotic treatment partially normalizes these metabolites [238]

In the article, Caffeine and seizures: A systematic review and quantitative analysis, it was found that caffeine lowered the efficacy of several drugs, especially topiramate

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