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HAMI3379, a small molecule with GPR17 antagonist properties [40], significantly attenuated the MDL29,951-mediated inhibition of F/I-stimulated GLP-1 secretion, shifting the IC 50 of MDL29,951 to 3600 nM (pIC 50 = 5.450.47) (Figure 3D)

These are different molecules with different molecular weights and different receptor binding profiles

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doi: 10.1016/j.neuint.2011.08.017 27 HumbertM.SitbonO.GuignabertC.SavaleL.BouclyA.Gallant-DewavrinM.et al