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Because it binds to the ghrelin receptor the same receptor responsible for hunger signaling, metabolic regulation, and cardiovascular modulation its side effect profile is shaped not only by elevated GH and downstream IGF-1 activity, but also by direct ghrelin receptor agonism across multiple biological systems

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A 2013 meta-analysis of 53 placebo-controlled trials evaluated the effect of vitamin C supplementation on the incidence, duration, or severity of the common cold when taken as a continuous daily supplement (43 trials) or as therapy upon onset of cold symptoms (10 trials) (212)

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[DOI] [PMC free article] [PubMed] [Google Scholar] 124.Petrilli M.A., Kranz T.M., Kleinhaus K., Joe P., Getz M., Johnson P., Chao M.V., Malaspina D