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There is no doubt that the GLP-1 landscape has significantly evolved in the last few years, from the early days of single hormone agonists like semaglutide to multi-hormone agonists of today such as tirzepatide and retatrutide

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METHODS Ten-week-old male ZSF1 obese rats with spontaneous HFpEF were treated with low-dose semaglutide (30 nmol/kg twice weekly, n=6) or vehicle for 16 weeks