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doi:10.3390/antiox12040834

The 5-on/2-off schedule involves injecting ipamorelin five days per week with two consecutive rest days

What the evidence shows The approval rests primarily on OASIS 4, a phase 3 randomised, double-blind, placebo-controlled trial of 307 adults with overweight or obesity and without diabetes, randomised 2:1 to oral semaglutide 25 mg or placebo for 64 weeks alongside lifestyle support (Wharton et al., 2025)

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