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[ref] Feedback loop: High levels of homocysteine increase inflammatory cytokines

A trail of research from lipoic acid to alpha-keto acid dehydrogenase complexes

These microbial changes correlate with higher lipopolysaccharide (LPS) and lower superoxide dismutase-1 levels (59, 60), which can lead to microbial translocation, systemic inflammation, and increased permeability of both the intestinal and blood-brain barriers (BBB), creating a vicious cycle (6165)

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Cumming RC, Lightfoot J, Beard K, Youssoufian H, O'Brien PJ and Buchwald M