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[17] The key component driving its effectiveness appears to be its ability to regulate adipokines particularly through increasing adiponectin expression while modulating leptin levels
A large multicenter database study confirmed this association
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Human PET studies using radioligands like [11C] DASB (a 5-HT transporter tracer) and [11C] raclopride (a DA D2/3 receptor antagonist) have validated these findings, showing reduced 5-HT transporter density in the raphe nuclei and blunted DA release in the striatum of chronic drinkers
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