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Hematologic Toxicities Hematologic side effects are most pronounced with cytotoxic oral agents such as temozolomide, etoposide, and cyclophosphamide , which target rapidly dividing hematopoietic precursors in the bone marrow

The large CASTA trial missed its main goal, though a smaller severe-stroke subgroup showed a favorable trend

Separately, research has examined DSIPs role in stress axis modulation specifically its effects on corticotropin-releasing hormone (CRH) and ACTH secretion suggesting a potential interface between the sleep regulatory system and the hypothalamic-pituitary-adrenal (HPA) axis

Summarizes wound/tissue-repair effects across animal models, but not veterinary clinical trials

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