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Anti-inflammatory activity is the earliest response, with cytokine suppression and nitric oxide modulation reducing swelling from 24 to 72 hours in acute injury models
Obesity management involves lifestyle interventions [7], pharmacotherapy [8, 9] and bariatric surgery [10]
Moreover, although randomized designs mitigate healthy-user bias, participants enrolled in long-term cardiovascular outcome trials may represent a healthier, more adherent subset of patients, potentially limiting generalizability
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