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Neuroimmune dysregulation is central Disrupted immunenervous system communication likely played a key role

Introduction Amodiaquine is a potent anti-malaria drug, however, rare but life-threatening idiosyncratic hepatotoxicity (1/15,500 patients) and agranulocytosis (1/2000 patients) have restricted its therapeutic use (Olliaro and Mussano, 2003

1 H-NMR (400 MHz, DMSO- d6 ): 11.34 (s, 1H), 11.10 (s, 1H), 8.16 (dd, J = 9.0, 2.7 Hz, 1H), 8.02 (d, J = 2.6 Hz, 1H), 7.37 (d, J = 9.0 Hz, 1H), 4.75 (s, 1H), 3.80 (d, J = 2.4 Hz, 1H), 2.702.55 (m, 2 H), 2.452.30 (m, 2 H), 2.101.85 (m, 2 H) ppm

Standard Protocol (Weeks 5-12) Daily Dose : 400 mcg subcutaneous injection Timing : Morning, fasted state preferred Frequency : Once daily Duration : 8-12 weeks continuous use The 400 mcg dose represents the optimal balance between efficacy and tolerability for most individuals

These effects are dose-dependent and typically resolve within 48 weeks as GLP-1 receptor density downregulates in the gut