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Its often mild, and some even mistake it for normal aging

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This section directly addresses the critical gap between animal research and established clinical efficacy

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A 1998 paper in the European Journal of Endocrinology characterised ipamorelin as the first selective growth-hormone secretagogue selective in the sense that it stimulated GH release from the anterior pituitary without elevating prolactin, ACTH, cortisol, or aldosterone (PMID 9849822)