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Due to its small molecular weight, H 2 could elevate forced vital capacity and decrease total respiratory system resistance (Feng et al., 2 gas may alleviate dyspnea of patients with COPD by inhibiting bronchiole mucus accumulation and goblet cell hyperplasia (Ning et al., 2013)

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Therefore, through the rational selection and combined use of various biomarkers and detection methods, it is possible to better monitor the pathological mechanisms in patients and assess the tumors sensitivity to and efficacy of treatment