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Tirzepatide may not fit research involving: Treatment-resistant, severe obesity (where maximum lipolysis is required) Models requiring increased energy expenditure Advanced non-alcoholic steatohepatitis (NASH) where liver fat oxidation is the primary target Retatrutide may not fit research involving: Subjects with a history of severe gastrointestinal sensitivity Models where extreme nausea or tachycardia (elevated heart rate) would confound the data Pure Type 2 Diabetes models (where Glucagon stimulation is counterproductive to glycemic control) Common Mistakes Mistake: Dosing Retatrutide at the same speed as Tirzepatide

Summary of where we are on GLP-1 and anesthesia The highly regarded Anesthesia Patient Safety Foundation has taken a strong stance on the issues involving GLP-1RAs, advising considerable caution on our part when caring for patients using the drugs

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Podocyte OTUD5 alleviates diabetic kidney disease through deubiquitinating TAK1 and reducing podocyte inflammation and injury

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