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Gene regulation NAD activates sirtuin proteins, which influence metabolism, stress resistance, and cellular longevity

This is consistent across the GLP-1 class semaglutide and tirzepatide users report the same pattern

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It blocks NNMT , an enzyme that wastes niacin (NAM) and methyl groups, so your cells keep more NAD for mitochondrial upkeep and more SAM for healthy methylation

Reduced calorie diet combined with NNMT inhibition establishes a metabolic memory