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TGF-1 promotes collagen synthesis through the following mechanisms, as determined by an examination of its mechanistic contribution to chronic kidney diseases and idiopathic pulmonary fibrosis: (i) activation of downstream signalling pathways, including the TGF-1/Smad pathway

[DOI] [PubMed] [Google Scholar] Singh B, Sharma RA

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Fourth, the molecular connection between SGLT2 inhibition and the activation of the hepatic AMPK/SIRT1/Nrf2 pathway is currently unclear, and indirect systemic effects cannot be ruled out