Similarly, discontinuation of a CYP3A4 inducer, such as rifampin, carbamazepine, and phenytoin, in Hydrocodone Bitartrate and Acetaminophen Tablets-treated patients may increase hydrocodone plasma concentrations and prolong opioid adverse reactions
2017YFC1103302)
Erdamar H, Demirci H, Yaman H, et al
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Sore throats and skin issues may occur in a lot of people, but unless these problems are severe, they do not indicate the discontinuation of the drug