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It is possible that the latter group might find a reduction in the efficacy of their HRT when using tirzepatide (for the same pharmacokinetic reasons discussed regarding contraception), but the likelihood and magnitude of this is unknown

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The short answer is that while both are effective, they work differently

According to the National Institute of Diabetes and Digestive and Kidney Diseases, adults who are overweight or obese should lose 5% to 10% of their body weight within 6 months for weight loss success and better outcomes (12)