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Mounjaro and valproate The MHRA Pregnancy Prevention Programme requires women of childbearing potential on valproate to use highly effective contraception because of the high risk of birth defects (around 11% of babies exposed to valproate in pregnancy) and neurodevelopmental disorders (up to 30-40%)

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Neuroscience Letters 472, 4752 (2010)

For constipation, increase fiber slowly and pair it with plenty of fluids

However, athletes considering these medications primarily for body composition changes (rather than health-related weight loss) should understand that muscle preservation requires deliberate, intensive effort