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This depletion occurs through several mechanisms: Direct oxidation of glutathione by UV-generated free radicals Increased consumption of glutathione in neutralizing UV-induced oxidative stress Impairment of glutathione synthesis pathways due to UV damage As glutathione levels decrease, the skin's natural defense mechanisms against UV-induced damage become significantly weakened
In females, an increase in estrus cycle length was observed at all dose levels, together with a small reduction in numbers of corpora lutea at 0.03 mg/kg/day
Studier, F
The safety profile in these patients was consistent with previous studies, with gastrointestinal side effects being the most common and generally manageable
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