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Specifically, tubacin inhibits the activity and expression of HDAC6, inhibits P62 and LC3-II, and upregulates the expression of beclin-1 (the key regulators of autophagy) by enhancing the acetylation of -tubulin at lysine 40 residues, thereby restoring autophagy levels and motility in AGE-treated podocytes (Liang et al., 2020)

Mistake 2: Shaking the vial to dissolve Vigorous shaking creates shearing forces between liquid layers that can damage peptide bonds

New delivery systems, including liposomes, nanoparticles, nanoemulsions and microneedles, have been used to improve drug solubility, increase skin permeability or reduce skin irritation, thus enhancing the therapeutic effect (Jing-Yan et al., 2020

They provide potential benefits beyond skin whitening, including detoxification and enhanced immune function

[DOI] [PubMed] [Google Scholar] 238.Lu YP