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The introduction of GLP-1 weight-loss drugs by Novo Nordisk (NYSE: NVO) may have changed the pharmaceutical industry forever

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Paper cited: Krger, N et al

In CRISPR-engineered iPSC-derived microglia and neurons, plus primary autopsy microglia and brain tissue, SORL1 deletion triggered endoplasmic reticulum stress, interferon signaling, lipid-droplet accumulation, and impaired phagocytosis