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Studies conducted on Nrf2 knockout mice have shown certain changes in the lens, including disruptions in cortical cell architecture, abnormal presence of nuclei in deeper lens regions, and ectopic nuclei in the posterior region

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Interestingly, the researchers found that lymphocytes in these patients had elevated levels of glutathione, which they hypothesize is a desperate, inadequate compensatory response by the cells trying to survive the relentless oxidative avalanche