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The main related signaling pathways and transformation factors are summarized as follows: NF-B, MAPK signaling pathway, JAK2/STAT3 signaling pathway, PI3K/Akt signaling pathway, AP-1, Nrf2, SIRT1, and HIF-1

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The comments and suggestions provided by the anonymous reviewers significantly improved this manuscript and we greatly appreciate their efforts

Los anlisis fueron realizados por personal capacitado del laboratorio de anlisis clnicos de la UMAE 48