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1) also appear to be complementary and mostly independent of their glucose-lowering properties [3, 12,13,14]

Additional experimental data support the protective role of GLP-1, including improved outcomes in DPP-4 knockout rats exposed to endotoxins and reduced mortality following GLP-1R activation ( Taken together, preclinical and clinical studies have demonstrated that GLP-1 receptor agonists exert pleiotropic effects extending beyond glycemic control, influencing multiple organ systems including the nervous, respiratory, hepatic, renal, cardiovascular, reproductive, and immune systems (Figure 4)

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Both ICV and IP administration of mGIPR-Ab led to similar magnitudes of weight loss relative to their respective controls (Fig