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& Spears, N
Induction of apoptosis by curcumin: mediation by glutathione S-transferase P1-1 inhibition
Key Takeaway: Skin discoloration occurs when the enzyme tyrosinase becomes overactive
Consistently, a recent long-term cohort study in hospital NS workers using a 1-1-3 rotating schedule reported significantly increased serum and urinary levels of 8-OHdG during the NS period, which remained elevated even one month after returning to DS, indicating persistent oxidative DNA damage induced by chronic NSW 69
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