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The medications have been shown to work most effectively when people are at their top doses for many months

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If you eat dinner early (56 p.m.) and inject at 89 p.m., you avoid taking the medication on a full stomach, which some research suggests reduces gastrointestinal upset

Inadequate use of vitamin B 12 , which may occur if antimetabolites for the vitamin are employed in the treatment of neoplasia Pernicious anemia is the most common cause of vitamin B 12 deficiency