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To investigate whether increasing the dose could help, Sean Wharton from the University of Toronto in Canada and his colleagues recruited over 1,000 obese adults in 11 countries, including the US, Canada, and parts of Europe

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There is then an active process moderated by the cholangiocytes of the biliary canaliculi which tends to dilute and alkalinise by the secretion of bicarbonate and chloride and reabsorption of glucose

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