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Figure 1 GSTs represent major detoxification enzymes with a protein size of ~25 kDa (Eaton and Bammler, 2000) and heavy metal resistance (Zhang et al., 2013

This phenomenon is predominantly caused by cobalamin release during hepatic cytolysis and/or decreased cobalamin clearance by the affected liver

Additionally, hepatotoxicity is a notable concern, particularly in patients with risk factors such as alcohol consumption, obesity, and diabetes, which can exacerbate liver damage

Gallant JN, Matthew EM, Cheng H, Harouaka R, Lamparella NE, Kunkel M,

doi: 10.1016/j.bbagen.2012.11.020 19 YangWSSriRamaratnamRWelschMEShimadaKSkoutaRViswanathanVSet al