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About 22% of patients reported dysesthesia (skin tingling) versus a lower rate on 2.4 mg

42 A phase 3 trial including adults with T2DM receiving orforglipron daily (3 mg, 12 mg or 36 mg) showed significant placebo-adjusted reductions in HbA 1c (1.07%) and weight loss (5.9%) at the highest dose

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The rapid degradation of GLP-1 in humans is primarily since the alanine in position 8 is readily recognized and cleaved by dipeptidyl peptidase (DPP-4)

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