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Multiple rodent models of PCOS, capitalizing mainly on the impact of androgen excess at different developmental windows, with variable penetrance in terms of reproductive and metabolic impairment, have been used in translational studies, in order to capture the phenotypic heterogeneity of the syndrome 38

J Cell Mol Med (2009) 13:422938.10.1111/j.1582-4934.2008.00463.x 81 LiuXSolehdinFCohenILGonzalezMGJenkinsECLewisMEet alPopulation- and family-based studies associate the MTHFR gene with idiopathic autism in simplex families