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Our study also found that NRF2, GPX4 and SOD1 expression levels were higher in the neoadjuvant chemotherapy-resistant group compared to the sensitive group, further supporting our hypothesis and demonstrating the adverse effects of GSH on chemotherapy in breast cancer patients

Since that MITF is an integrated transcriptional factor governing the expressions of a plenty of target genes implicated in cell-cycle progression (CDK2, CCND1, p21, p16, and p27), cell differentiation (TYR, TYPR1, DCT, RAB27, MYO5a), and invasive capacity (GMPR, DIAPH1), 79 the cellular phenotype regulated by MITF is possibly attributed to the mixture of dysregulated molecules involved in distinct biological aspects

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