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While A1C control matters for preventing microvascular complications (eye, kidney, nerve damage), cardiovascular events represent the leading cause of death in diabetes

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Leptin A hormone produced by fat cells that signals satiety to the brain

The larger benefit with the additional agonism of GIPr seems to be its effect on weight loss

These medications slow down the emptying of the stomach, reduce appetite, and increase insulin release, leading to better control over blood sugar levels and fewer food cravings