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While active IGF-IR can compensate EGFR inhibition, activation of the EGFR pathway also contributes to anti-IGF-IR drugs resistance in cancer [174, 175]

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These results point to a marked decline not only in immediate use but also in long-term craving and drive

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95% CI, 0.28-0.84)

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Mild side effects, such as nausea, bloating, constipation, or fatigue, can also occur as the body adjusts to treatment

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