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Instead they tend to build gradually and steadily over time

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- Lntigo simple: son manchas pigmentadas oscuras, pequeas y aisladas , que se encuentran en cualquier sitio, sin relacin con la exposicin a los rayos ultravioletas - Sindrome de Peutz-Jeghers: son manchas pigmentadas de la mucosa bucal, los labios, los dedos de las manos y los pies , y que pueden acompaarse de plipos gastrointestinales