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Collectively, confinement is a pathophysiologically relevant cue that can influence tumor progression significantly by altering the modes and mechanisms of cancer cell migration, promoting genomic instability, and inducing gene expression changes, which trigger EMT and provide resistance to therapeutic agents

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For the PE-only CPT code 98975, the RUC's recommendations include a Remote musculoskeletal therapy monitoring program enrollment fee. We did not propose a price for this input at this time as we believe this type of fee has not traditionally been included as a form of direct PE and would constitute forms of indirect PE under our methodology

Researchers initiated treatment at doses approximately ten times lower, gradually increasing them every four weeks for a total of 16 weeks