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Risks & Considerations While Retatrutide shows promise, experts caution about possible side effects: Bone fractures and kidney issues have been reported in some trial participants
[DOI] [PMC free article] [PubMed] [Google Scholar] 43.Wadden T.A., Hollander P., Klein S., Niswender K., Woo V., Hale P.M., Aronne L., NN8022-1923 Investigators Weight maintenance and additional weight loss with liraglutide after low-calorie-diet-induced weight loss: The SCALE Maintenance randomized study
4 Efforts to extend the life of native GLP-1 led to the development of human GLP-1 analogs liraglutide, albiglutide, dulaglutide, and semaglutide
The mechanisms promoting drug resistance include the following: first, at the pharmacokinetic level, the overactivation of drug efflux pumps is mediated by ATP-binding cassette transporters (ABC transporters)
Therefore, patients should review safe alternatives with a qualified provider
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