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It should be emphasized that the addition of any antihyperglycemic agent to a patients current insulin therapy has the potential to increase the risk of insulin-induced hypoglycemia, particularly at the start of therapy

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At the highest doses, retatrutide seems to promise more significant weight loss than existing GLP-1s on the market but as dosage increases, so does the risk of side effects, mostly mild-to-moderate gastrointestinal issues, although one case of pancreatitis occurred in a patient on the 12mg dose during the phase II trial