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AIM2 suppresses ferroptosis by promoting proteasomal degradation of FOXO3a, a transcriptional activator of ACSL4 a key enzyme that esterifies PUFAs into peroxidation-prone phospholipids essential for ferroptosis execution (259)

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Safety and efficacy of tirzepatide as an add-on to single oral antihyperglycaemic medication in patients with type 2 diabetes in Japan (SURPASS J-combo): a multicentre, randomised, open-label, parallel-group, phase 3 trial

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