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Retatrutide is an investigational once-weekly injectable medication that activates three hormone receptors (GLP-1, GIP, and glucagon) to promote weight loss

Niacin deficiency or pellagra may result from inadequate dietary intake of NAD precursors, including tryptophan

Research in animal models has shown sustained reductions in body weight gain and increased fat oxidation over extended treatment periods, with individual results varying considerably based on adherence to diet and exercise protocols alongside peptide use

Harvard Health notes that dietary fiber mimics some of the fullness signals that GLP1 medications produce naturally