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Centrally acting anti-obesity medicines with evidence for use in older adults Only 2% of the Contrave Obesity Research (COR) trials, evaluating naltrexone-bupropion, were older adult participants [109, 110], and hence have not been discussed here

The difference between chronological age and retinal age, which can be assessed with optical coherence tomography (OCT) and fundus imaging, is another potential biomarker of ageing and mortality 21,22 , but this approach has not yet been validated in people with MS

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