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Disruption of iron homeostasis not only triggers intracellular oxidative stress but also activates both central and peripheral immune responses, establishing a ironimmunity-neurodegeneration feedback loop that amplifies inflammation and exacerbates neuronal damage

Regulation of selenium metabolism and transport

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(A) qPCR data showing the normalized mRNA expression of NRF2-regulated genes ( Gclm , Nqo1 , Srxn1 , Hmox1 , Gsr ) in RAW264.7 Ms with (+) and without (-) oxLDL loading and LPS stimulation for 6 h (n = 45)