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In searching Reddit communities dedicated to GLP-1 drugs, I found lots of normal people whose experience backed up that research: They had long tried to lose weight but could never quite meet their goals until they went on a GLP-1 drug

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Almost 20% of the identified patients who initiated GLP1-RA stopped treatment within the first 12 months, the majority due to undesired side effects or a lack of effect

Like mazdutide, it uses a C20 fatty diacid for albumin binding and weekly pharmacokinetics, but the second receptor target is GIP rather than glucagon

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