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This estimate agrees relatively well with the range of 12.4% for low-molecular weight copper pool in blood serum determined in seven independent studies by ultrafiltration 10

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The findings compiled in this table directly inform Section 9 (Discussion) in three key areas: regarding clinical significance, it supports the prioritization of stratified interventions based on nutrients with strong evidence (e.g., dietary fiber and EPA/DHA), particularly for inflammatory depression subtypes (65, 124)

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The model is missing the unstructured N terminus of 76 amino acids, as well as several loops connecting the transmembrane helices (Fig 5B)